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Hsp70 associates with Rictor and is required for mTORC2 formation and activity
mTORC2 is a multiprotein kinase composed of mTOR, mLST8, PRR5, mSIN1 and Rictor. The complex is insensitive to rapamycin and has demonstrated functions controlling cell growth, motility, invasion and cytoskeletal assembly. mTORC2 is the major hydrophobic domain kinase which renders Akt fully active...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2512964/ https://ncbi.nlm.nih.gov/pubmed/18505677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.05.086 |
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