Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

In Salmonella enterica, aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme. When purH is eliminated in an otherwise wild-type strain, AICAR accumulates and indirectly inhibits synthesis of the...

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Udgivet i:Microb Cell
Main Authors: Bazurto, Jannell V., Dearth, Stephen P., Tague, Eric D., Campagna, Shawn R., Downs, Diana M.
Format: Artigo
Sprog:Inglês
Udgivet: Shared Science Publishers OG 2017
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798407/
https://ncbi.nlm.nih.gov/pubmed/29417056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2018.02.613
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