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Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside (AICAr) induced apoptosis in multiple myeloma cells

To investigate the mechanism by which AICAr induces apoptosis in multiple myeloma (MM) cells, we performed an unbiased metabolomics screen. AICAr had selective effects on nucleotide metabolism, resulting in an increase in purine metabolites and a decrease in pyrimidine metabolites. The most striking...

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Autori principali: Bardeleben, Carolyne, Sharma, Sanjai, Reeve, Joseph R., Bassilian, Sara, Frost, Patrick, Hoang, Bao, Shi, Yijiang, Lichtenstein, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707969/
https://ncbi.nlm.nih.gov/pubmed/23585020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1042
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