Structure Property Relationships of Carboxylic Acid Isosteres

[Image: see text] The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying principle is that by maintaining the features of the carboxylic acid critical for biological activity, but appropriately modify...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Lassalas, Pierrik, Gay, Bryant, Lasfargeas, Caroline, James, Michael J., Tran, Van, Vijayendran, Krishna G., Brunden, Kurt R., Kozlowski, Marisa C., Thomas, Craig J., Smith, Amos B., Huryn, Donna M., Ballatore, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833640/
https://ncbi.nlm.nih.gov/pubmed/26967507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01963
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