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Carboxylic Acid (Bio)Isosteres in Drug Design
The carboxylic acid functional group can be an important constituent of a pharmacophore, however, the presence of this moiety can also be responsible for significant drawbacks, including metabolic instability, toxicity, as well as limited passive diffusion across biological membranes. To avoid some...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
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2013
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640829/ https://ncbi.nlm.nih.gov/pubmed/23361977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200585 |
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