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Carboxylic Acid (Bio)Isosteres in Drug Design
The carboxylic acid functional group can be an important constituent of a pharmacophore, however, the presence of this moiety can also be responsible for significant drawbacks, including metabolic instability, toxicity, as well as limited passive diffusion across biological membranes. To avoid some...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640829/ https://ncbi.nlm.nih.gov/pubmed/23361977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200585 |
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