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Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2)-Receptor Antagonists

Cyclopentane-1,3-diones are known to exhibit pK(a) values typically in the range of carboxylic acids. To explore the potential of the cyclopentane-1,3-dione unit as a carboxylic acid isostere, the physical-chemical properties of representative congeners were examined and compared with similar deriva...

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Bibliografische gegevens
Hoofdauteurs: Ballatore, Carlo, Soper, James, Piscitelli, Francesco, James, Michael, Huang, Longchuan, Atasoylu, Onur, Huryn, Donna M., Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R., Smith, Amos B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188681/
https://ncbi.nlm.nih.gov/pubmed/21863799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200980u
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