The orphan nuclear receptor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Molecular mechanisms linking the sympathetic stress response and inflammation remain enigmatic. Here we demonstrate that the transcription factor Nr4a1 regulates production of norepinephrine (NE) in macrophages, thereby limiting experimental autoimmune encephalomyelitis (EAE), a mouse model of multi...

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Publicado no:Nat Immunol
Main Authors: Shaked, Iftach, Hanna, Richard N., Shaked, Helena, Chodaczek, Grzegorz, Nowyhed, Heba N., Tweet, George, Tacke, Robert, Basat, Alp Bugra, Mikulski, Zbigniew, Togher, Susan, Miller, Jacqueline, Blatchley, Amy, Salek-Ardakani, Shahram, Darvas, Martin, Kaikkonen, Minna U., Thomas, Graham, Lai-Wing-Sun, Sonia, Rezk, Ayman, Bar-Or, Amit, Glass, Christopher K., Bandukwala, Hozefa, Hedrick, Catherine C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833087/
https://ncbi.nlm.nih.gov/pubmed/26523867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3321
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