The orphan nuclear receptor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Molecular mechanisms linking the sympathetic stress response and inflammation remain enigmatic. Here we demonstrate that the transcription factor Nr4a1 regulates production of norepinephrine (NE) in macrophages, thereby limiting experimental autoimmune encephalomyelitis (EAE), a mouse model of multi...

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Publicat a:Nat Immunol
Autors principals: Shaked, Iftach, Hanna, Richard N., Shaked, Helena, Chodaczek, Grzegorz, Nowyhed, Heba N., Tweet, George, Tacke, Robert, Basat, Alp Bugra, Mikulski, Zbigniew, Togher, Susan, Miller, Jacqueline, Blatchley, Amy, Salek-Ardakani, Shahram, Darvas, Martin, Kaikkonen, Minna U., Thomas, Graham, Lai-Wing-Sun, Sonia, Rezk, Ayman, Bar-Or, Amit, Glass, Christopher K., Bandukwala, Hozefa, Hedrick, Catherine C.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833087/
https://ncbi.nlm.nih.gov/pubmed/26523867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3321
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