The orphan nuclear receptor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Molecular mechanisms linking the sympathetic stress response and inflammation remain enigmatic. Here we demonstrate that the transcription factor Nr4a1 regulates production of norepinephrine (NE) in macrophages, thereby limiting experimental autoimmune encephalomyelitis (EAE), a mouse model of multi...

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Pubblicato in:Nat Immunol
Autori principali: Shaked, Iftach, Hanna, Richard N., Shaked, Helena, Chodaczek, Grzegorz, Nowyhed, Heba N., Tweet, George, Tacke, Robert, Basat, Alp Bugra, Mikulski, Zbigniew, Togher, Susan, Miller, Jacqueline, Blatchley, Amy, Salek-Ardakani, Shahram, Darvas, Martin, Kaikkonen, Minna U., Thomas, Graham, Lai-Wing-Sun, Sonia, Rezk, Ayman, Bar-Or, Amit, Glass, Christopher K., Bandukwala, Hozefa, Hedrick, Catherine C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833087/
https://ncbi.nlm.nih.gov/pubmed/26523867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3321
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