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Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8(+) T Cell Expansion and Effector Function through Direct Repression of Irf4
The transcription factor IFN regulatory factor (IRF)4 was shown to play a crucial role in the protective CD8(+) T cell response; however, regulation of IRF4 expression in CD8(+) T cells remains unclear. In this article, we report a critical role for Nr4a1 in regulating the expansion, differentiation...
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| Publicat a: | J Immunol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
AAI
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4592102/ https://ncbi.nlm.nih.gov/pubmed/26363057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403027 |
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