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Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8(+) T Cell Expansion and Effector Function through Direct Repression of Irf4

The transcription factor IFN regulatory factor (IRF)4 was shown to play a crucial role in the protective CD8(+) T cell response; however, regulation of IRF4 expression in CD8(+) T cells remains unclear. In this article, we report a critical role for Nr4a1 in regulating the expansion, differentiation...

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Vydáno v:J Immunol
Hlavní autoři: Nowyhed, Heba N., Huynh, Tridu R., Thomas, Graham D., Blatchley, Amy, Hedrick, Catherine C.
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592102/
https://ncbi.nlm.nih.gov/pubmed/26363057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403027
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