Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

Kappa opioid receptor (KOR) modulation is a promising target for drug discovery efforts due to KOR involvement in pain, depression, and addiction behaviors. We recently reported a new class of triazole KOR agonists that displays significant bias toward G protein signaling over βarrestin2 recruitment...

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Gepubliceerd in:ACS Chem Neurosci
Hoofdauteurs: Lovell, Kimberly M., Frankowski, Kevin J., Stahl, Edward L., Slauson, Stephen R., Yoo, Euna, Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830356/
https://ncbi.nlm.nih.gov/pubmed/25891774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00092
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