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Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus

The kappa opioid receptor (KOR) is involved in mediating pruritus; agonists targeting this receptor have been used to treat chronic intractable itch. Conversely, antagonists induce an inch response at the site of injection. As a G protein-coupled receptor (GPCR), the KOR has potential for signaling...

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Pubblicato in:Neuropharmacology
Autori principali: Morgenweck, Jenny, Frankowski, Kevin J., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739521/
https://ncbi.nlm.nih.gov/pubmed/26318102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.08.027
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