An Improved Antagonist Radiotracer for the Kappa Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989

The kappa opioid receptors (KOR) are implicated in a number of neuropsychiatric diseases and addictive disorders. Positron Emission Tomography (PET) with radioligands provides a means to image the KOR in vivo and investigate its function in health and disease. The purpose of this study was to develo...

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Bibliographic Details
Published in:J Nucl Med
Main Authors: Zheng, Ming-Qiang, Kim, Su Jin, Holden, Daniel, Lin, Shu-fei, Need, Anne, Rash, Karen, Barth, Vanessa, Mitch, Charles, Navarro, Antonio, Kapinos, Michael, Maloney, Kathleen, Ropchan, Jim, Carson, Richard E., Huang, Yiyun
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826283/
https://ncbi.nlm.nih.gov/pubmed/24854795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.114.138701
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