Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer (11)C-LY2795050

The κ-opioid receptor (KOR) is thought to play an important therapeutic role in a wide range of neuropsychiatric and substance abuse disorders, including alcohol dependence. LY2456302 is a recently developed KOR antagonist with high affinity and selectivity and showed efficacy in the suppression of...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Naganawa, Mika, Dickinson, Gemma L., Zheng, Ming-Qiang, Henry, Shannan, Vandenhende, Francois, Witcher, Jennifer, Bell, Robert, Nabulsi, Nabeel, Lin, Shu-Fei, Ropchan, Jim, Neumeister, Alexander, Ranganathan, Mohini, Tauscher, Johannes, Huang, Yiyun, Carson, Richard E.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727157/
https://ncbi.nlm.nih.gov/pubmed/26628406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229278
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