Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer (11)C-LY2795050

The κ-opioid receptor (KOR) is thought to play an important therapeutic role in a wide range of neuropsychiatric and substance abuse disorders, including alcohol dependence. LY2456302 is a recently developed KOR antagonist with high affinity and selectivity and showed efficacy in the suppression of...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Pharmacol Exp Ther
Main Authors: Naganawa, Mika, Dickinson, Gemma L., Zheng, Ming-Qiang, Henry, Shannan, Vandenhende, Francois, Witcher, Jennifer, Bell, Robert, Nabulsi, Nabeel, Lin, Shu-Fei, Ropchan, Jim, Neumeister, Alexander, Ranganathan, Mohini, Tauscher, Johannes, Huang, Yiyun, Carson, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Neuropharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727157/
https://ncbi.nlm.nih.gov/pubmed/26628406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229278
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares