Determination of the In vivo Selectivity of a new Kappa Opioid Receptor Antagonist PET Tracer [(11)C]LY2795050 in the Rhesus Monkey

[(11)C]LY2795050 is a novel kappa-selective antagonist PET tracer. The in vitro binding affinities (K(i)) of LY2795050 at the kappa opioid (KOR) and mu opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was...

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Publicado no:J Nucl Med
Main Authors: Kim, Su Jin, Zheng, Ming-Qiang, Nabulsi, Nabeel, Labaree, David, Ropchan, Jim, Najafzadeh, Soheila, Carson, Richard E., Huang, Yiyun, Morris, Evan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824998/
https://ncbi.nlm.nih.gov/pubmed/23918735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.118877
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