Determination of the In vivo Selectivity of a new Kappa Opioid Receptor Antagonist PET Tracer [(11)C]LY2795050 in the Rhesus Monkey

[(11)C]LY2795050 is a novel kappa-selective antagonist PET tracer. The in vitro binding affinities (K(i)) of LY2795050 at the kappa opioid (KOR) and mu opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was...

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Veröffentlicht in:J Nucl Med
Hauptverfasser: Kim, Su Jin, Zheng, Ming-Qiang, Nabulsi, Nabeel, Labaree, David, Ropchan, Jim, Najafzadeh, Soheila, Carson, Richard E., Huang, Yiyun, Morris, Evan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824998/
https://ncbi.nlm.nih.gov/pubmed/23918735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.118877
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