Synthesis and Evaluation of [(11)C]LY2795050 as a Novel Kappa Opioid Receptor Antagonist Radiotracer for PET Imaging

Kappa opioid receptors (KOR) are believed to be involved in the pathophysiology of depression, anxiety disorders, drug abuse and alcoholism. To date, only one tracer, the kappa opioid receptor agonist [(11)C]GR103545, has been reported to be able to image KOR in primates. The goal of the present stu...

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Detalhes bibliográficos
Main Authors: Zheng, Ming-Qiang, Nabulsi, Nabeel, Kim, Su Jin, Tomasi, Giampaolo, Lin, Shu-fei, Mitch, Charles, Quimby, Steven, Barth, Vanessa, Rash, Karen, Masters, John, Navarro, Antonio, Seest, Eric, Morris, Evan E., Carson, Richard E., Huang, Yiyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775344/
https://ncbi.nlm.nih.gov/pubmed/23353688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.109512
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