Novel (18)F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of (18)F-LY2459989 in Nonhuman Primates

The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other central nervous system disorders and, thus, is an important target for drug development. We previously developed several (11)C-labeled PET radiotracers for KOR imaging in humans. Here we report the synthesis and eva...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Nucl Med
Egile Nagusiak: Li, Songye, Cai, Zhengxin, Zheng, Ming-Qiang, Holden, Daniel, Naganawa, Mika, Lin, Shu-Fei, Ropchan, Jim, Labaree, David, Kapinos, Michael, Lara-Jaime, Teresa, Navarro, Antonio, Huang, Yiyun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society of Nuclear Medicine 2018
Gaiak:
Radiochemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750518/
https://ncbi.nlm.nih.gov/pubmed/28747521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.195586
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