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Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics

Studies have shown κ-opioid receptor (KOR) abnormalities in addictive disorders, other central nervous system diseases, and Alzheimer’s disease. We have developed the first set of agonist (11)C-GR103545 and antagonist (11)C-LY2795050 radiotracers for PET imaging of KOR in humans. Nonetheless, (11)C-...

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Bibliografski detalji
Izdano u:J Nucl Med
Glavni autori: Li, Songye, Zheng, Ming-Qiang, Naganawa, Mika, Kim, Sujin, Gao, Hong, Kapinos, Michael, Labaree, David, Huang, Yiyun
Format: Artigo
Jezik:Inglês
Izdano: Society of Nuclear Medicine 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604690/
https://ncbi.nlm.nih.gov/pubmed/30630942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.220517
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