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Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics
Studies have shown κ-opioid receptor (KOR) abnormalities in addictive disorders, other central nervous system diseases, and Alzheimer’s disease. We have developed the first set of agonist (11)C-GR103545 and antagonist (11)C-LY2795050 radiotracers for PET imaging of KOR in humans. Nonetheless, (11)C-...
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| Publicado no: | J Nucl Med |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society of Nuclear Medicine
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6604690/ https://ncbi.nlm.nih.gov/pubmed/30630942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.220517 |
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