GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are expressed and myeloid and dendritic cell potential is...

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Publicado en:Nat Commun
Autores principales: Van de Walle, Inge, Dolens, Anne-Catherine, Durinck, Kaat, De Mulder, Katrien, Van Loocke, Wouter, Damle, Sagar, Waegemans, Els, De Medts, Jelle, Velghe, Imke, De Smedt, Magda, Vandekerckhove, Bart, Kerre, Tessa, Plum, Jean, Leclercq, Georges, Rothenberg, Ellen V., Van Vlierberghe, Pieter, Speleman, Frank, Taghon, Tom
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823830/
https://ncbi.nlm.nih.gov/pubmed/27048872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11171
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