Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor–ligand interactions mediate this process. Whereas Delta-like 4 supp...

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Main Authors: Van de Walle, Inge, Waegemans, Els, De Medts, Jelle, De Smet, Greet, De Smedt, Magda, Snauwaert, Sylvia, Vandekerckhove, Bart, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Gridley, Thomas, Wang, Tao, Koch, Ute, Radtke, Freddy, Taghon, Tom
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620353/
https://ncbi.nlm.nih.gov/pubmed/23530123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121798
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