Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor–ligand interactions mediate this process. Whereas Delta-like 4 supp...

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Bibliografiska uppgifter
Huvudupphovsmän: Van de Walle, Inge, Waegemans, Els, De Medts, Jelle, De Smet, Greet, De Smedt, Magda, Snauwaert, Sylvia, Vandekerckhove, Bart, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Gridley, Thomas, Wang, Tao, Koch, Ute, Radtke, Freddy, Taghon, Tom
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620353/
https://ncbi.nlm.nih.gov/pubmed/23530123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121798
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