Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

The T cell receptor (TCR)γδ and the pre-TCR promote survival and maturation of early thymocyte precursors. Whether these receptors also influence γδ versus αβ lineage determination is less clear. We show here that TCRγδ gene rearrangements are suppressed in TCRαβ transgenic mice when the TCRαβ is ex...

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Bibliografiska uppgifter
Huvudupphovsmän: Terrence, Kathleen, Pavlovich, Christian P., Matechak, Errin O., Fowlkes, B.J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2000
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193230/
https://ncbi.nlm.nih.gov/pubmed/10952723
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