Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor–ligand interactions mediate this process. Whereas Delta-like 4 supp...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Van de Walle, Inge, Waegemans, Els, De Medts, Jelle, De Smet, Greet, De Smedt, Magda, Snauwaert, Sylvia, Vandekerckhove, Bart, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Gridley, Thomas, Wang, Tao, Koch, Ute, Radtke, Freddy, Taghon, Tom
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2013
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620353/
https://ncbi.nlm.nih.gov/pubmed/23530123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121798
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы