Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

γδ and αβ T cells have unique roles in immunity and both originate in the thymus from T‐lineage committed precursors through distinct but unclear mechanisms. Here, we show that Notch1 activation is more stringently required for human γδ development compared to αβ‐lineage differentiation and performe...

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Pubblicato in:EMBO Rep
Autori principali: Dolens, Anne‐Catherine, Durinck, Kaat, Lavaert, Marieke, Van der Meulen, Joni, Velghe, Imke, De Medts, Jelle, Weening, Karin, Roels, Juliette, De Mulder, Katrien, Volders, Pieter‐Jan, De Preter, Katleen, Kerre, Tessa, Vandekerckhove, Bart, Leclercq, Georges, Vandesompele, Jo, Mestdagh, Pieter, Van Vlierberghe, Pieter, Speleman, Frank, Taghon, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202205/
https://ncbi.nlm.nih.gov/pubmed/32255245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949006
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