Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

γδ and αβ T cells have unique roles in immunity and both originate in the thymus from T‐lineage committed precursors through distinct but unclear mechanisms. Here, we show that Notch1 activation is more stringently required for human γδ development compared to αβ‐lineage differentiation and performe...

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Publicado no:EMBO Rep
Main Authors: Dolens, Anne‐Catherine, Durinck, Kaat, Lavaert, Marieke, Van der Meulen, Joni, Velghe, Imke, De Medts, Jelle, Weening, Karin, Roels, Juliette, De Mulder, Katrien, Volders, Pieter‐Jan, De Preter, Katleen, Kerre, Tessa, Vandekerckhove, Bart, Leclercq, Georges, Vandesompele, Jo, Mestdagh, Pieter, Van Vlierberghe, Pieter, Speleman, Frank, Taghon, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202205/
https://ncbi.nlm.nih.gov/pubmed/32255245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949006
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