Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells

Melatonin, a molecule produced throughout the animal and plant kingdoms, and berberine, a plant derived agent, both exhibit antitumor and multiple biological and pharmacological effects, but they have never been combined altogether for the inhibition of human lung cancers. In this study, we investig...

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Pubblicato in:Oncotarget
Autori principali: Lu, Jian-Jun, Fu, Lingyi, Tang, Zhipeng, Zhang, Changlin, Qin, Lijun, Wang, Jingshu, Yu, Zhenlong, Shi, Dingbo, Xiao, Xiangsheng, Xie, Fangyun, Huang, Wenlin, Deng, Wuguo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823085/
https://ncbi.nlm.nih.gov/pubmed/26672764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6407
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