Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers

Upregulated expression and activation of human telomerase reverse transcriptase (hTERT) is a hallmarker of lung tumorigenesis. However, the mechanism underlying the aberrant hTERT activity in lung cancer cells remains poorly understood. In this study, we found the transcriptional co-activator CBP as...

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Pubblicato in:Oncotarget
Autori principali: Guo, Wei, Lu, Jianjun, Dai, Meng, Wu, Taihua, Yu, Zhenlong, Wang, Jingshu, Chen, Wangbing, Shi, Dingbo, Yu, Wendan, Xiao, Yao, Yi, Canhui, Tang, Zhipeng, Xu, Tingting, Xiao, Xiangsheng, Yuan, Yuhui, Liu, Quentin, Du, Guangwei, Deng, Wuguo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253439/
https://ncbi.nlm.nih.gov/pubmed/25294805
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