Ku80 cooperates with CBP to promote COX-2 expression and tumor growth

Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double strands, as a new binding protein of the COX-2 gene...

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Vydáno v:Oncotarget
Hlavní autoři: Xiao, Yao, Wang, Jingshu, Qin, Yu, Xuan, Yang, Jia, Yunlu, Hu, Wenxian, Yu, Wendan, Dai, Meng, Li, Zhenglin, Yi, Canhui, Zhao, Shilei, Li, Mei, Du, Sha, Cheng, Wei, Xiao, Xiangsheng, Chen, Yiming, Wu, Taihua, Meng, Songshu, Yuan, Yuhui, Liu, Quentin, Huang, Wenlin, Guo, Wei, Wang, Shusen, Deng, Wuguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480734/
https://ncbi.nlm.nih.gov/pubmed/25797267
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