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Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation
The structural basis of allosteric signaling in G protein-coupled receptors (GPCRs) is important in guiding design of therapeutics and understanding phenotypic consequences of genetic variation. The Evolutionary Trace (ET) algorithm previously proved effective in redesigning receptors to mimic the l...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822589/ https://ncbi.nlm.nih.gov/pubmed/26979958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516579113 |
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