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Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors
G protein-coupled receptors for dopamine and serotonin control signaling pathways targeted by many psychoactive drugs. A puzzle is how receptors with similar functions and nearly identical binding site structures, such as D2 dopamine receptors and 5-HT2A serotonin receptors, could evolve a mechanism...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867884/ https://ncbi.nlm.nih.gov/pubmed/20385837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914877107 |
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