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Determinants of Endogenous Ligand Specificity Divergence among Metabotropic Glutamate Receptors

To determine the structural origins of diverse ligand response specificities among metabotropic glutamate receptors (mGluRs), we combined computational approaches with mutagenesis and ligand response assays to identify specificity-determining residues in the group I receptor, mGluR1, and the group I...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Kang, Hye Jin, Wilkins, Angela D., Lichtarge, Olivier, Wensel, Theodore G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317032/
https://ncbi.nlm.nih.gov/pubmed/25519912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622233
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