Determinants of Endogenous Ligand Specificity Divergence among Metabotropic Glutamate Receptors

To determine the structural origins of diverse ligand response specificities among metabotropic glutamate receptors (mGluRs), we combined computational approaches with mutagenesis and ligand response assays to identify specificity-determining residues in the group I receptor, mGluR1, and the group I...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Kang, Hye Jin, Wilkins, Angela D., Lichtarge, Olivier, Wensel, Theodore G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317032/
https://ncbi.nlm.nih.gov/pubmed/25519912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622233
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