Selectivity and Evolutionary Divergence of Metabotropic Glutamate Receptors for Endogenous Ligands and G Proteins Coupled to Phospholipase C or TRP Channels

To define the upstream and downstream signaling specificities of metabotropic glutamate receptors (mGluR), we have examined the ability of representative mGluR of group I, II, and III to be activated by endogenous amino acids and catalyze activation of G proteins coupled to phospholipase C (PLC), or...

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Detalhes bibliográficos
Main Authors: Kang, Hye Jin, Menlove, Kit, Ma, Jianpeng, Wilkins, Angela, Lichtarge, Olivier, Wensel, Theodore G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208005/
https://ncbi.nlm.nih.gov/pubmed/25193666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574483
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