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Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors

The D2 dopamine receptor and the serotonin 5-hydroxytryptamine 2A receptor (5-HT2A) are closely-related G-protein–coupled receptors (GPCRs) from the class A bioamine subfamily. Despite structural similarity, they respond to distinct ligands through distinct downstream pathways, whose dysregulation i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Terrón-Díaz, María E., Wright, Sara J., Agosto, Melina A., Lichtarge, Olivier, Wensel, Theodore G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916503/
https://ncbi.nlm.nih.gov/pubmed/31676688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008068
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