mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Precise coordination of cell growth, proliferation and differentiation is essential for the development of multicellular organisms. Here, we report that although the mechanistic target of rapamycin complex 1 (mTORC1) activity is required for chondrocyte growth and proliferation, its inactivation is...

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Vydáno v:Nat Commun
Hlavní autoři: Yan, Bo, Zhang, Zhongmin, Jin, Dadi, Cai, Chen, Jia, Chunhong, Liu, Wen, Wang, Ting, Li, Shengfa, Zhang, Haiyan, Huang, Bin, Lai, Pinglin, Wang, Hua, Liu, Anling, Zeng, Chun, Cai, Daozhang, Jiang, Yu, Bai, Xiaochun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822018/
https://ncbi.nlm.nih.gov/pubmed/27039827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11151
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