mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Precise coordination of cell growth, proliferation and differentiation is essential for the development of multicellular organisms. Here, we report that although the mechanistic target of rapamycin complex 1 (mTORC1) activity is required for chondrocyte growth and proliferation, its inactivation is...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Yan, Bo, Zhang, Zhongmin, Jin, Dadi, Cai, Chen, Jia, Chunhong, Liu, Wen, Wang, Ting, Li, Shengfa, Zhang, Haiyan, Huang, Bin, Lai, Pinglin, Wang, Hua, Liu, Anling, Zeng, Chun, Cai, Daozhang, Jiang, Yu, Bai, Xiaochun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822018/
https://ncbi.nlm.nih.gov/pubmed/27039827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11151
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