PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy

During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy. Using multiple mouse genetics models,...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Nishimori, Shigeki, Lai, Forest, Shiraishi, Mieno, Kobayashi, Tatsuya, Kozhemyakina, Elena, Yao, Tso-Pang, Lassar, Andrew B., Kronenberg, Henry M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483522/
https://ncbi.nlm.nih.gov/pubmed/30843886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97903
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