mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Precise coordination of cell growth, proliferation and differentiation is essential for the development of multicellular organisms. Here, we report that although the mechanistic target of rapamycin complex 1 (mTORC1) activity is required for chondrocyte growth and proliferation, its inactivation is...

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Publicat a:Nat Commun
Autors principals: Yan, Bo, Zhang, Zhongmin, Jin, Dadi, Cai, Chen, Jia, Chunhong, Liu, Wen, Wang, Ting, Li, Shengfa, Zhang, Haiyan, Huang, Bin, Lai, Pinglin, Wang, Hua, Liu, Anling, Zeng, Chun, Cai, Daozhang, Jiang, Yu, Bai, Xiaochun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822018/
https://ncbi.nlm.nih.gov/pubmed/27039827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11151
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