Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis

Accumulation of apoptosis-resistant fibroblasts is a hallmark of pulmonary fibrosis. We hypothesized that disruption of inhibitor of apoptosis protein (IAP) family proteins would limit lung fibrosis. We first show that transforming growth factor-β1 and bleomycin increase X-linked IAP (XIAP) and cell...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Ashley, Shanna L., Sisson, Thomas H., Wheaton, Amanda K., Kim, Kevin K., Wilke, Carol A., Ajayi, Iyabode O., Subbotina, Natalya, Wang, Shaomeng, Duckett, Colin S., Moore, Bethany B., Horowitz, Jeffrey C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821054/
https://ncbi.nlm.nih.gov/pubmed/26378893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0148OC
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