Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis

INTRODUCTION: Impaired plasminogen activation (PA) is causally related to the development of lung fibrosis. Prior studies demonstrate that enhanced PA in the lung limits the severity of scarring following injury and in vitro studies indicate that PA promotes matrix degradation and fibroblast apoptos...

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Detalhes bibliográficos
Publicado no:Thromb Haemost
Main Authors: Horowitz, Jeffrey C., Tschumperlin, Daniel J., Kim, Kevin K., Osterholzer, John J., Subbotina, Natalya, Ajayi, Iyabode O., Teitz-Tennenbaum, Seagal, Virk, Ammara, Dotson, Megan, Liu, Fei, Sicard, Delphine, Jia, Shijing, Sisson, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011401/
https://ncbi.nlm.nih.gov/pubmed/31705517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0039-1697953
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