Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

Myofibroblasts are crucial to the pathogenesis of tissue fibrosis. Their formation of stress fibers results in the release of myocardin-related transcription factor (MRTF), a transcriptional coactivator of serum response factor (SRF). MRTF-A (Mkl1)-deficient mice are protected from lung fibrosis. We...

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Udgivet i:Am J Pathol
Main Authors: Sisson, Thomas H., Ajayi, Iyabode O., Subbotina, Natalya, Dodi, Amos E., Rodansky, Eva S., Chibucos, Lauren N., Kim, Kevin K., Keshamouni, Venkateshwar G., White, Eric S., Zhou, Yong, Higgins, Peter D.R., Larsen, Scott D., Neubig, Richard R., Horowitz, Jeffrey C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2015
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380846/
https://ncbi.nlm.nih.gov/pubmed/25681733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.12.005
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