Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

Myofibroblasts are crucial to the pathogenesis of tissue fibrosis. Their formation of stress fibers results in the release of myocardin-related transcription factor (MRTF), a transcriptional coactivator of serum response factor (SRF). MRTF-A (Mkl1)-deficient mice are protected from lung fibrosis. We...

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Publicado no:Am J Pathol
Main Authors: Sisson, Thomas H., Ajayi, Iyabode O., Subbotina, Natalya, Dodi, Amos E., Rodansky, Eva S., Chibucos, Lauren N., Kim, Kevin K., Keshamouni, Venkateshwar G., White, Eric S., Zhou, Yong, Higgins, Peter D.R., Larsen, Scott D., Neubig, Richard R., Horowitz, Jeffrey C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380846/
https://ncbi.nlm.nih.gov/pubmed/25681733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.12.005
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