LIG4 mediates Wnt signalling-induced radioresistance

Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA ligase in DNA double-strand break...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jun, Sohee, Jung, Youn-Sang, Suh, Han Na, Wang, Wenqi, Kim, Moon Jong, Oh, Young Sun, Lien, Esther M., Shen, Xi, Matsumoto, Yoshihisa, McCrea, Pierre D., Li, Lei, Chen, Junjie, Park, Jae-Il
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820809/
https://ncbi.nlm.nih.gov/pubmed/27009971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10994
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