TMEM9 Promotes Intestinal Tumorigenesis via v-ATPase-Activated Wnt/β-Catenin Signaling

Vesicular acidification and trafficking are associated with various cellular processes. However, their pathologic relevance to cancer remains elusive. We identified transmembrane protein 9 (TMEM9) as a vesicular acidification regulator. TMEM9 is highly upregulated in colorectal cancer (CRC). Proteom...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Jung, Youn-Sang, Jun, Sohee, Kim, Moon Jong, Ho Lee, Sung, Suh, Han Na, Lien, Esther M., Jung, Hae-Yun, Lee, Sunhye, Zhang, Jie, Yang, Jung-In, Ji, Hong, Wu, Ji Yuan, Wang, Wenqi, Miller, Rachel K., Chen, Junjie, McCrea, Pierre D, Kopetz, Scott, Park, Jae-Il
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261670/
https://ncbi.nlm.nih.gov/pubmed/30374053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0219-8
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