TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis

How Wnt signaling is orchestrated in liver regeneration and tumorigenesis remains elusive. Recently, we identified transmembrane protein 9 (TMEM9) as a Wnt signaling amplifier. TMEM9 facilitates v-ATPase assembly for vesicular acidification and lysosomal protein degradation. TMEM9 is highly expresse...

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Publicat a:Hepatology
Autors principals: Jung, Youn-Sang, Stratton, Sabrina A., Lee, Sung Ho, Kim, Moon-Jong, Jun, Sohee, Zhang, Jie, Zheng, Biyun, Cervantes, Christopher L, Cha, Jong-Ho, Barton, Michelle C., Park, Jae-Il
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647947/
https://ncbi.nlm.nih.gov/pubmed/32380568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31305
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