Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration

Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knock-in (Tert(TCE/+)) mouse model, we found that Tert+ cells are long-term label...

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Pubblicato in:Cell Rep
Autori principali: Suh, Han Na, Kim, Moon Jong, Jung, Youn-Sang, Lien, Esther M., Jun, Sohee, Park, Jae-Il
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726811/
https://ncbi.nlm.nih.gov/pubmed/29186692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.118
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