PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

The underlying mechanisms how self-renewing cells are controlled in regenerating tissues and cancer remain ambiguous. PAF (PCNA-associated factor) modulates DNA repair via PCNA. Also, PAF hyperactivates Wnt/β-catenin signaling independently of PCNA interaction. We found that PAF is expressed in inte...

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Publicat a:Dev Cell
Autors principals: Kim, Moon Jong, Xia, Bo, Suh, Han Na, Lee, Sung Ho, Jun, Sohee, Lien, Esther M., Zhang, Jie, Chen, Kaifu, Park, Jae-Il
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854208/
https://ncbi.nlm.nih.gov/pubmed/29533773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.02.010
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