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PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
The underlying mechanisms how self-renewing cells are controlled in regenerating tissues and cancer remain ambiguous. PAF (PCNA-associated factor) modulates DNA repair via PCNA. Also, PAF hyperactivates Wnt/β-catenin signaling independently of PCNA interaction. We found that PAF is expressed in inte...
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| Publicado no: | Dev Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5854208/ https://ncbi.nlm.nih.gov/pubmed/29533773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.02.010 |
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