PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis

The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF (PCLAF/KIAA0101) drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. PAF is highly expressed in...

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Vydáno v:Mol Cell
Hlavní autoři: Kim, Moon Jong, Cervantes, Christopher, Jung, Youn-Sang, Zhang, Xiaoshan, Zhang, Jie, Lee, Sung Ho, Jun, Sohee, Litovchick, Larisa, Wang, Wenqi, Chen, Junjie, Fang, Bingliang, Park, Jae-Il
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052288/
https://ncbi.nlm.nih.gov/pubmed/33626321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.02.001
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