PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis

The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF (PCLAF/KIAA0101) drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. PAF is highly expressed in...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Kim, Moon Jong, Cervantes, Christopher, Jung, Youn-Sang, Zhang, Xiaoshan, Zhang, Jie, Lee, Sung Ho, Jun, Sohee, Litovchick, Larisa, Wang, Wenqi, Chen, Junjie, Fang, Bingliang, Park, Jae-Il
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052288/
https://ncbi.nlm.nih.gov/pubmed/33626321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.02.001
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