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A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function
Ku heterodimer is a DNA binding protein with a prominent role in DNA repair. Here, we investigate whether and how Ku impacts the DNA damage response by acting as a post‐transcriptional regulator of gene expression. We show that Ku represses p53 protein synthesis and p53‐mediated apoptosis by binding...
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| Pubblicato in: | EMBO Rep |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818778/ https://ncbi.nlm.nih.gov/pubmed/26964895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541181 |
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